Novel compound offers improved defense against fentanyl overdoses

Jay McLaughlin, Ph.D., a professor in the UF College of Pharmacy, is part of a research team that has identified a novel compound aimed at improving the treatment of opioid overdoses.

Press release from UF Health


GAINESVILLE, Fla. — Scientists at the University of Florida have identified a novel compound aimed at improving the treatment of opioid overdoses, which claimed the lives of more than 81,000 Americans last year.

The discovery could combat the devastating epidemic of opioid-related deaths, driven predominantly by the proliferation of fentanyl. The highly potent synthetic opioid is a pain reliever and among the nation’s most abused substances.

“Fentanyl is driving the need to find better treatments for opioid overdoses,” said Jay McLaughlin, Ph.D., a professor of pharmacodynamics in the UF College of Pharmacy. “Every opioid death is preventable, highlighting the immediate need to improve the treatment options.”

In a study published in the journal Nature, a team of researchers from six laboratories at Washington University School of Medicine in St. Louis, Stanford University, and UF report how they identified and tested the compound 368. When paired with the drug naloxone, compound 368 increased the medication’s ability to reverse the lethal effects of opioid overdose.

Naloxone, also known by its brand name Narcan, blocks the effects of opioids and can temporarily reverse an opioid overdose. The drug acts as an antagonist — binding to opioid receptor sites on nerve cells, thereby preventing fentanyl and other opioids from activating them.

Narcan can quickly restore normal breathing in an individual whose respiration has slowed or stopped because of an opioid overdose.

“We have known for a long time that Narcan can save lives,” McLaughlin said. “However, Narcan is short-acting and tends to wear off quickly. If an individual takes a massive dose of fentanyl, then they will go back into respiratory distress when the Narcan wears off.”

According to McLaughlin, Narcan also triggers withdrawal symptoms in patients dependent on opioids. The research team identified that when compound 368 is combined with low doses of Narcan, it can reverse respiratory depression without inducing withdrawal symptoms.

Narcan and the compound 368 were found to bind at different sites of the opioid receptor, enabling them to complement each other in blocking opioids like fentanyl. This dual binding keeps Narcan attached to the receptor longer, providing extended protection at lower doses of the antagonist against the harmful effects of fentanyl.

“Determining the optimal Narcan dosage has been a persistent challenge for health care providers,” McLaughlin said. “In time, combining a smaller amount of Narcan with our compound may circumvent the danger of patients undergoing opioid withdrawal.”

The latest study builds on new insights into the structure and function of opioid receptors, advancing research published by the same team in November 2022. They previously reported in Nature how modifications to fentanyl’s chemical structure maintained its pain-relieving properties while reducing harmful side effects.

  • “Scientists at the University of Florida” will make sure that the city and county commissioners get plenty of free samples. “Determining the optimal Narcan dosage has been a persistent challenge for” them, that’s why their commission meeting minutes and votes can get so weird.

  • How about closing the border? As long as Dems run the country that border will remain open. It’s treasonous
    and Joe doesn’t care.

  • Here’s a Novel idea…

    How about not being a POS drug addict and just stop doing illegal drugs.

    If they want to kill themselves, let them….it will be less of a burden on society.

      • Lou:

        Not at all…I am very compassionate..

        we should help them if they want out.

        The blue cities even give away free needles…

  • >